Receptors - hot stuff

Teaser Image
Image

This collection of chemical and molecular structures has been assembled to help students explore chemicals that elicit a sense of heat and/or pain by binding certain receptors. All the chemical and molecular structures below can be viewed in Molecule World on the iPad or Molecule World for iPhone.  

Displaying 1 - 7 of 7

Type Structure Description PDB ID Download Structure
An MW Collection
Image

Receptors for capsaicin and wasabi, and capsaicin, wasabi, and spider toxin.  Use the link on the right to download all the structures at once.

Document
hot_stuff.mwc (646.53 KB)
Image

Capsaicin is a chemical made by chili peppers that contributes to a sensation of heat.

Document
capsaicin.sdf.gz (2.21 KB)
MMDB
Image

Capsaicin receptor, also called the TrpVI Ion channel.

3J5P
Document
3J5P.cn3 (930.68 KB)
MMDB
Image

Capsaicin receptor bound to spider toxin.

3J5Q
Document
3J5Q.cn3 (867.66 KB)
MMDB
Image

The "double-knot" spider toxin binds to the TrpV receptor and causes a sensation of heat and pain.  

1I25
Document
Huwentoxin.cn3 (30.75 KB)
MMDB
Image

TrpA1 ion channel.  Allyl isothiocyanate from wasabi binds to this receptor and causes a sensation of heat and pain.

3J9P
Document
3J9P.cn3 (1.21 MB)
Image

Allyl isothiocyanate is the chemical in wasabi that creates a sensation of heat.

Document