Watching the chIPs roll in,
then I watch them roll away again,
I'm just sitting on the DNA,
(sung to the tune of "Sitting on the dock of the bay" by Otis Redding)
Hesselberth et.al. recently published a paper about digital genomic
footprinting that blew me away because it has so much potential. The authors used DNAse I and Next Generation DNA Sequencing to map every site in the yeast genome where a protein might be sitting.
Since I used to do similar kinds of experiments, albeit on a much, much smaller scale, this sort of publication boggles my mind. ... Read more