RNA

By @finchtalk (Todd Smith)

In 2014 and beyond Finchtalk will be contributing to Digitalbio’s blog at this site. We kick off 2014 with Finchtalk’s traditional post on the annual database issue from Nucleic Acids Research (NAR).

Biological data and databases are ever expanding. This year was no exception as the number of databases tracked by NAR grew from 1512 to 1552. In the leadoff introduction [1] the authors summarize this year’s issue and the status of the NAR index. The 21st issue includes 185 articles with 58 new databases and 123 updates. In the 1552 database repository ... Read more

by Todd Smith


Biological data and databases are ever expanding. This year was no exception as the number of databases tracked by Nucleic Acids Research (NAR) grew from 1512 to 1552. In the leadoff introduction [1] the authors summarize this year’s issue and the status of the NAR index. The 21st issue includes 185 articles with 58 new databases and 123 updates. In the 1552 database repository, 193 had their URLs corrected and 24 were removed because they were deemed obsolete.


In the leadoff introduction [1] the authors ... Read more

For the past few months, the shake-up that began with Next Generation DNA Sequencing has been forcing me to adjust to a whole new view of things going on inside of a cell. We've been learning things these past two years that are completely changing our understanding of the genome and how it works and it's clear we're never going back to the simple view we had before.

What's changed? The two most striking changes, to me at least, are the new views of the way the genome is put together and what the cell does with the information.

They just don't assemble ... Read more

Before mammals, before dinosaurs, before bacteria, or plants, there was something else; a protocell containing RNA.

i-4c756422efd338ecba1f0d41066e8ec1-ribozyme.gif
The Exploring Origins Project has excellent animations of protocells, a timeline of life's evolution, and best of all- fantastic ... Read more

This structure is called a "kissing loop" and I find that name just a bit odd, given the source of the structure.

i-f452c2f14f97c250b00ff83ebce31479-kissing_loop.gif



Now, here's the puzzle: Why would I say that the name "kissing loop" is ironic?Read more