Quoth Dr. Stemwedel, from Adventures in Science and Ethics. In the case of Universities and four-yr colleges, I completely agree. If you're looking for job training, go to a community college. This post is in response to one of the comments from the other day. This commenter expressed frustration at ...
It must be spring. Summer course announcements are popping up everywhere and this site is no exception. Last Friday, I posted an announcement about our summer bioinformatics course in Alaska, June 27-29th. This week, I have a couple more conferences to announce. Naturally, I'll be at both of them, leading ...
I made this video (below the fold) to illustrate the steps involved in making a phylogenetic tree. The basic steps are to: Build a data set Align the sequences Make a tree In the class that I'm teaching, we're making these trees in order to compare sequences from our metagenomics ...
What do you call a biologist who uses bioinformatics tools to do research, but doesn't program? You don't know? Neither does anyone else. The names we use People who practice biology are known by many names, so many, that the number of names almost reflects the diversity of biology itself ...
It's a Solexa data directory. I've held off on blogging about Next Generation Sequencing here, but now that one of my colleagues has started blogging about it, it seems like a good time to write a little about FinchTalk, our company blog. We've decided that we can serve an educational ...
Okay, all of you biochemists and molecular biology types. I have a puzzle for you that I found by accident during a lecture. Yes, I was the one lecturing and the notes will be posted soon. In the meantime, here's your puzzle: What's unusual about this pair of bases? tags ...
One of the things that drives me crazy on occasion is nomenclature. Well, maybe not just nomenclature, it's really the continual changes in the nomenclature, and the time it takes for those changes to ripple through various databases and get reconciled with other kinds of information. And the realization that ...
Do mosquitoes get the mumps? Part V. A general method for finding interesting things in GenBank This is the last in a five part series on an unexpected discovery of a paramyxovirus in mosquitoes and a general method for finding other interesting things. In this last part, I discuss a ...
If you've ever looked at an evolutionary tree, contemplated phylogeny, cladistics, or the like, you're probably aware that Joe Felsenstein is one of the leaders of the pack. And you will certainly enjoy, this interview that Blind Scientist has posted. I wouldn't advise reading the interview to learn about doing ...
yep, I've become a videoblogger, at least sometimes. See the first video below. Be kind in the comments, this is a new thing for me. This video introduces the different blast programs, discusses word size, and how blastn works, the blastn score and the E value. The treatment is light ...
I suppose I should have expected this. I thought it might be fun to see what the databases had to say about turkeys. So, I queried the NCBI databases, found a taxonomy reference, and started clicking related links to see pictures of the different species. Why? Because it would be ...
I often get questions about bioinformatics, bioinformatics jobs and career paths. Most of the questions reflect a general sense of confusion between creating bioinformatics resources and using them. Bioinformatics is unique in this sense. No one confuses writing a software package like Photoshop with being a photographer, yet for some ...
A potential link between lung cancer and human papilloma virus may make parents even more glad about vaccinating their children with Gardasil®. Not only are the children protected against viruses that commonly cause cervical cancer, they may be protected against some forms of lung cancer as well. The April 25th ...
What’s the first you think about when you see a spider? Running away? Danger? Fairies? Spiderman? Do you wonder if spider silk is really strong enough to stop a train, like they showed in Spiderman 2? Whatever your thoughts, you’re probably not thinking about 3D printing in space. Yet, the ...
What do genetic testing and genealogy have in common? The easy answer is that they're both used by people who are trying to find out who they are, in more ways than one. Another answer is that both tests can involve DNA sequence data. And that leads us to another ...
Have you ever wondered how to find things in the NCBI databases? Maybe you tried to find something but didn't know how it was spelled. Or maybe you tried to use a common name like "pig" or "deer" to find information in a database, not knowing that all the organism ...
Three (or more) operating systems times three (or more) versions of software with bugs unique to one or systems (that I don't have) means too many systems for me to manage teaching. Thank the FSM they're not using Linux, too. (Let me see that would be Ubuntu Linux, RedHat Linux ...
Sometimes when you go digging through the databases, you find unexpected things. When I was researching the previous posts on insulin structure and insulin evolution, I found something curious indeed. Human insulin, colored by rainbow. Image from the Molecule World iPad app by Digital World Biology. I wanted to find ...
It seems kind of funny to be thinking of anti-freeze at the moment, with heat waves blanketing the U.S., but all this hot weather makes me miss winter. And so I decided it was time to re-post this from the original DigitalBio. Winter is coming soon, my bike ride to ...
For the past few years, I've been collaborating with a friend, Dr. Rebecca Pearlman, who teaches introductory biology at the Johns Hopkins University. Her students isolate bacteria from different environments on campus, use PCR to amplify the 16S ribosomal RNA genes, send the samples to the JHU core lab for ...
What do you do after you've used DNA sequencing to identify the bacteria, viruses, or other organisms in the environment? What's the next step? This four part video series covers those next steps. In this part, we learn that a surprisingly large portion of bioinformatics, or any type of informatics ...
This is third video in our series on analyzing the DNA sequences that came from bacteria on the JHU campus. In this video, we use a pivot table to count all the different types of bacteria that students found in 2004 and we make a pie graph to visualize the ...
Do different kinds of biomes (forest vs. creek) support different kinds of bacteria? Or do we find the same amounts of each genus wherever we look? Those are the questions that we'll answer in this last video. We're going to use pivot tables and count all the genera that live ...
Considering that several genomes that have been sequenced in the past decade, it seems amazing in retrospect, that the first complete bacterial genome sequence was only published 12 years ago (1). Now, the Genome database at the NCBI lists 450 complete microbial genomes (procaryotes and archea), 1476 genomes from eucaryotes ...
"How much do I love you? I'll tell you no lie. How deep is the ocean? How high is the sky?" - Irving Berlin The other installments are here: Part I: Introduction Part II: Sequencing strategies Part III: Reads and chromats Part V: checking out the library We all know ...
About a week ago, I offered to answer questions about subjects that I've either worked with, studied or taught. I haven't had many questions yet, but I can certainly answer the ones I've had so far. Today, I'll answer the first question: How do you sequence a genome? Before we ...
Shotgun sequencing. Sounds like fun. Speculations on the origin of the phrase I think that this term came from shotgun cloning. In the early days of gene cloning before cDNA, PCR, or electroporation; molecular biologists would break genomic DNA up into lots of smaller pieces, package DNA in lambda phage ...
BCRs (antibodies) and TCRs (T cell receptors) are the recognition molecules of our immune system; the molecules they bind are called antigens. BCRs and TCRs are similar in many ways, but their differences form the core of how self and non-self are recognized.
tags: PZ's morning post about a bear killing a moose in someone's yard ( they do live in Alaska, after all), reminded me that it's time to make an announcement about our upcoming course. No, no, no! We're not going to kill any moose on the premises. We're going to ...
If you haven't, then hustle over to Mendel's Garden for a wonderful story about the monk and his life as a scientist, check out Gene Genie for best drawing of Craig Venter that I've ever seen; and if you're into computers, take a good long look at the lightning edition ...
By @finchtalk (Todd Smith) We kick off 2014 with Finchtalk’s traditional post on the annual database issue from Nucleic Acids Research (NAR). Biological data and databases are ever expanding. This year was no exception as the number of databases tracked by NAR grew from 1512 to 1552. In the leadoff ...
It's time for the annual blog about the annual Nucleic Acids Research (NAR) database issue. This is the 24th database issue for NAR and the seventh blog for @finchtalk. Like most years I have no idea what I'm going to write about until I start reading the new issue. Something ...
I don't usually publish press releases, but I'm making an exception for this one, since your's truly is one of the Co-PI's. If you're a teacher within commuting distance of Seattle, the schedule and sign up information is here. NSF AWARDS $1.3 MILLION TO NWABR FOR BIOINFORMATICS EDUCATION Innovative Technology ...
Welcome to the fourth edition of Bio::Blogs! This is the carnival where we explore topics at the intersection of computing, biology, and sometimes a bit human behavior. In this edition, we consider issues with annotation, agonize over standards, explore the question of whether or not it's possible to tame those ...
The bioinformatics classes that I teach use web services and web sites as much as possible, but I still find that it's helpful to have programs on our classroom computers. Here is a list of my favorite desktop programs for those of you who might want to add some bioinformatics ...
Registration has opened a bit late this year, but it's always tricky when large programs change hands. The Chautauqua Short Course program for College Teachers is no different. In fact, as far as I know, we may still be waiting for the National Science Foundation to make a final decision ...
Last spring, I gave my first hands-on workshop in working with Next Generation Sequencing data at the Eighth Annual UT-ORNL-KBRIN Bioinformatics Summit at Fall Creek Falls State Park in Tennessee. The p roceedings from that conference are now on-line at BMC Bioinformatics and it's fun to look back and reflect ...
Note to self: doing live BLAST searches during a lecture is not a good idea. Would Julia Child make her viewers watch the food bake? Standing in front of a class and waiting for results to appear, makes me realize how much instructors can learn a lot from watching Julia ...
It's pretty common these days to pick up an issue of Science or Nature and see people ranting about GenBank (1). Many of the rants are triggered, at least in part, by a wide-spread misunderstanding of what GenBank is and how it works. Perhaps this can be solved through education ...
Vizzini: He didn't fall? Inconceivable! Inigio: You keep using that word. I do not think it means what you think it means. - William Goldman, The Princess Bride Excuse me while I temporarily interrupt the genome sequencing series to define a word. Artifacts in the classroom It's disorienting. You learn ...
One of the commenters on a previous post, pointed out that proteases have pretty diverse structures, even though they also share a common function. What else could I do? I had to take a look. I found structures for chymotrypsin (from a cow) and subtilisin (from a soil bacteria, Bacillus ...
Do you want to learn how to use some cool biotechnology and bioinformatics methods in your college or high school class? If you're on the East coast, the best place to go is the Fralin Biotechnology Conference at Virignia Tech, July 18-21st. ( Yes, it's the same Virgina Tech, and ...
No more delays! BLAST away! Time to blast. Let's see what it means for sequences to be similar. First, we'll plan our experiment. When I think about digital biology experiments, I organize the steps in the following way: A. Defining the question B. Making the data sets C. Analyzing the ...
No biology course is complete these days without learning how to do a BLAST search. Herein, I describe an assignment and an animated tutorial that teachers can readily adopt and use, and give teachers a hint for obtaining the password-protected answer key. Development of the tutorial and the activity were ...
Last week I found a bug in the new NCBI BLAST interface. Of course, I reported it to the NCBI help desk so it will probably get fixed sometime soon. But it occurred to me, especially after seeing people joke about whether computer science is really a science or not ...
I had an enlightening experience recently, after I wrote some bioinformatics activities, under contract, for a community college. At the end of the project, the person at the college asked me if the activities were anything like the things that a " bioinformatics technician" would do on the job. tags ...
What do people do in bioinformatics software companies? tags: , In our old conference room, in our last office, we used to have this little card on a stand, entitled "Sun's universe of stars." Over the years, we watched several of those stars blink out, one by one. The card ...
I don't usually blog about work for wide variety of reasons. But, last week, since I wanted to write about bioinformatics software companies, I broke with tradition and wrote about Geospiza as an example. Naturally, I got some feedback about this. Some people liked it, but one of the most ...
In this, and the next post in this series, I want to answer some of the questions that came up in the comments. One of the commenters on part II wrote that: For most academic biology groups, however, being a bioinformatics specialist is a dead end job! People in these ...
