Siamese cats

Teaser Image
Image

These structures can be used to show the affect of a frameshift mutation and to examine temperature sensitive mutations.

Read more about the biochemistry of melanin production.

Displaying 1 - 6 of 6

Type Structure Description PDB ID Download Structure
An MW Collection
Image

Use the link on the right to download the collection.

Document
Siamese_cats.mwc (152.39 KB)
Image

Tyrosinase converts tyrosine to dopaquinone in the first step of the pathway for synthesizing melanin. 

Document
Tyrosine.sdf.gz (1.49 KB)
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Tyrosinase converts tyrosine to dopaquinone in the first step of the pathway for synthesizing melanin. 

Document
Dopaquinone.sdf.gz (1.48 KB)
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Dopaquinone is converted to melanin in the second step of the pathway for synthesizing melanin. 

Document
Melanin.sdf.gz (1.98 KB)
MMDB
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This tryrosinase structure is from a bacteria, Bacillus megaterium.  The sequence is similar to the sequence of the tyrosinase protein in humans and other animals like cats and dogs.

4P6R
Document
4P6R-1.cn3 (278.22 KB)
MMDB
Image

This tryrosinase structure is identical to the other one from Bacillus. Use this for modeling.  

To show the affect of the delection, copy the sequence below, select it in the structure, and hide the unselected sequences.  Do this one row at a time.

KYRVRKNVLHLTDTEKRDFVRTVLILKEKGIYDRYIAWHGAAGKFHTPPGSDRNA
AHMSSAFLPWHREYLLRFERDLQSINPEVTLPYWEWETDAQMQDPSQSQIWSADF
MGGNGNPIKDFIVDTGPFAAGRWTTIDEQGNPSGGLKRNFGATKEAPTLPTRDDVL
4P6R
Document
4P6R-2.cn3 (278.22 KB)