Influenza-drug-resistance

These structures are from aligned pairs of drug-sensitive and drug-resistant influenza proteins bound to different types of antiviral drugs. Comparing the pairs of structures shows how a single base mutation can allow a virus to become resistant to a drug. The drugs include Oseltamivir (Tamil®), Zanamivir (Relenza®), Peramivir (Rapivab®), Lanamivir, and two drug candidates (G20 and G28). The normal substrate, sialic acid, is also shown below.

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Displaying 1 - 36 of 36

Type		Structure Description	PDB ID	Download Structure
An MW Collection	Image	To view the collection, you will need to download and install the iPad version of Molecule World. Once Molecule World is installed on your iPad, return to this page and download the entire collection at once by selecting the mwc file. Click the link on the right to download the entire collection of drug sensitive and resistant mutants of Influenza neuramindases. View Details		Document influenza2.mwc (3.42 MB)
	Image	Sialic acid is the normal substrate for the influenza neuraminidase protein. View Details
	Image	Oseltamivir, or Tamiflu® is used to treat respiratory infections with the influenza virus. View Details
PDB	Image	A drug sensitive influenza N2 neuraminidase bound to Oseltamivir (G39). View Details	4GZP
PDB	Image	D151g, drug resistant variant of influenza N2 neuraminidase protein bound to Oseltamivir (G39) with glycine acid at position 151 instead of aspartic acid. View Details	4GZT
PDB	Image	A drug sensitive influenza B neuraminidase bound to Oseltamivir (G39). View Details	4CPM
PDB	Image	I220l, drug resistant variant of Influenza B neuraminidase bound to Oseltamivir (G39) with leucine at position 220 instead of isoleucine. View Details	4CPY
PDB	Image	A drug sensitive Influenza N1 neuraminidase from the 2009 pandemic strain bound to Oseltamivir (G39). View Details	4B7R
PDB	Image	I223r, drug resistant influenza N1 neuraminidase from the 2009 pandemic strain bound to Oseltamivir (G39) with an arginine at position 223 instead of isoleucine. View Details	4B7J
MMDB	Image	A drug sensitive influenza N9 neuraminidase bound to Oseltamivir (G39). View Details	2QWK
MMDB	Image	R292k, drug resistant influenza N9 neuraminidase bound to Oseltamivir (G39), with lysine replacing arginine. View Details	2QWH
PDB	Image	A drug sensitive influenza N9 neuraminidase bound to Oseltamivir (G39). View Details	4MWQ
PDB	Image	R294k, drug resistant influenza N9 neuraminidase bound to Oseltamivir (G39) with lysine at position 294 instead of arginine. View Details	4MWW
PDB	Image	N294, drug sensistive influenza N1 neuraminidase bound to Oseltamivir (G39). View Details	2HU0_chainB
PDB	Image	N294s, drug resistant influenza N1 neuraminidase with serine at position 294 instead of asparagine bound to Oseltamivir (G39). View Details	2CL2
	Image	Lanamivir is used to treat respiratory infections with the influenza virus View Details
PDB	Image	A drug sensitive influenza N9 neuraminidase bound to Lanamivir (LNV) View Details	4MWU
PDB	Image	R294k, drug resistant influenza N9 neuraminidase bound to Lanamivir (LNV) with lysine at position 294 instead of arginine. View Details	4MWY
MMDB	Image	A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ). View Details	1L7F
MMDB	Image	E119g, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ) with a glycine at position 119 instead of glutamic acid. View Details	1L7G
	Image	Peramivir is used to treat respiratory infections with the influenza virus. View Details
MMDB	Image	A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ). View Details	1L7F
MMDB	Image	R292k, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ), with a lysine at position 292 instead of arginine. View Details	1L7H
PDB	Image	A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ). View Details	4MWV
PDB	Image	R294k, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ) with lysine at position 294 instead of arginine. View Details	4MX0
	Image	Zanamivir (Relenza®) is used to treat respiratory infections with the influenza virus. View Details
PDB	Image	A drug sensitive influenza N1 neuraminidase from the 2009 pandemic strain bound to Zanamivir (ZMR). View Details	4B7Q
PDB	Image	I223r, drug resistant influenza N1 neuraminidase from the 2009 pandemic strain bound to Zanamivir (ZMR) with arginine at position 223 instead of isoleucine. View Details	4B7N
PDB	Image	A drug sensitive influenza N9 neuraminidase bound to Zanamivir (ZMR). View Details	4MWR
PDB	Image	R294k, drug resistant influenza N9 neuraminidase bound to Zanamivir (ZMR), with arginine at position 294 instead of lysine. View Details	4MWX
	Image	G20 is a compound being tested as a treatment for respiratory infections with the influenza virus. View Details
MMDB	Image	A drug sensitive influenza N9 neuraminidase bound to a new drug (G20). View Details	2QWI
MMDB	Image	R292k, drug resistant, influenza N9 neuraminidase bound to a new drug (G20), with lysine at position 292 instead of arginine. View Details	2QWF
	Image	G28 is a compound being tested as a treatment for respiratory infections with the influenza virus. View Details
MMDB	Image	A drug sensitive influenza N9 neuraminidase bound to a new drug (G28). View Details	2QWJ
MMDB	Image	R292k, drug resistant influenza N9 neuraminidase bound to a new drug (G28), with lysine at position 292 instead of arginine. View Details	2QWJ