BRCA1

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This collection of chemical and molecular structures has been assembled to complement the Bio-ITEST Genetic Testing curriculum strand. All the structures below can be viewed in Molecule World on the iPad.   ****Includes NEW structures!****

Displaying 1 - 16 of 16

Type Structure Description PDB ID Download Structure
An MW Collection
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To view this collection of BRCA1 structures, you will need to download and install the iPad version of Molecule World.  Once Molecule World is installed on your iPad, return to this page and download the entire collection at once by selecting the mwc file.  

Document
brca1.mwc (625.19 KB)
PDB
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BRCA1 carboxyl terminal end with BRCT repeats, bound to CtIP phosphopeptide, a partner in detecting and repairing DNA.

1Y98
MMDB
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BRCA1 carboxyl terminal end, contains BRCT repeats and the CtIP binding domain.  M1775

1JNX
MMDB
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BRCA1 carboxyl terminal end, BRCT repeats.  Contains the CtIP binding domain and M1775r mutation.

1N5O
PDB
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BRCA1 carboxyl terminal end, BRCT repeats.  Contains the CtIP binding domain and M1775k mutation.

1N5O
PDB
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BRCA1 carboxyl terminal end with BRCT repeats, bound to CtIP phosphopeptide, a partner in detecting and repairing DNA. Contains the normal amino acid G1656.

1Y98
PDB
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BRCA1 carboxyl terminal end, BRCT repeats. Modeling was used to align 3PXA to 1Y98 and add the CtIP phosphopeptide. Contains the G1656d missense mutation.

3PXA
PDB
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BRCA1 carboxyl terminal end with BRCT repeats, bound to CtIP phosphopeptide, a partner in detecting and repairing DNA. Contains the normal amino acid R1699.

1Y98
PDB
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BRCA1 carboxyl terminal end with BRCT repeats. Modeling was used to align 3PXC to 1Y98 and add the CtIP phosphopeptide. Contains the R1699q missense mutation.

3PXC
PDB
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BRCA1 carboxyl terminal end with BRCT repeats, bound to CtIP phosphopeptide, a partner in detecting and repairing DNA. Contains the normal amino acid T1700.

1Y98
PDB
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BRCA1 carboxyl terminal end with BRCT repeats.   Modeling was used to align 3PXB to 1Y98 and add the CtIP phosphopeptide.  Contains the T1700a missense mutation.

3PXB
PDB
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BRCA1 carboxyl terminal end with BRCT repeats, bound to CtIP phosphopeptide, a partner in detecting and repairing DNA. Contains the normal amino acid V1809.

1Y98
PDB
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BRCA1 carboxyl terminal end with BRCT repeats.   Modeling was used to align 1T2U to 1Y98 and add the CtIP phosphopeptide. Contains the V1809f missense mutation.

1T2U
PDB
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BRCA1 carboxyl terminal end with BRCT repeats, bound to CtIP phosphopeptide, a partner in detecting and repairing DNA. Contains the normal amino acid D1840.

1Y98
PDB
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BRCA1 carboxyl terminal end with BRCT repeats.   Modeling was used to align 3K16 to 1Y98 and add the CtIP phosphopeptide. Contains the D1840t missense mutation.

3K16
MMDB
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A short chain of double-stranded DNA showing hydrogens. Hydrogens are present because this structure was solved by NMR.

1NAJ