These structures are from aligned pairs of drug-sensitive and drug-resistant influenza proteins bound to different types of antiviral drugs. Comparing the pairs of structures shows how a single base mutation can allow a virus to become resistant to a drug. The drugs include Oseltamivir (Tamil®), Zanamivir (Relenza®), Peramivir (Rapivab®), Lanamivir, and two drug candidates (G20 and G28). The normal substrate, sialic acid, is also shown below.
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Structures in the collection
| Type | Description | Download structure |
|---|---|---|
| An MW Collection |
 To view the collection, you will need to download and install the iPad version of Molecule World. Once Molecule World is installed on your iPad, return to this page and download the entire collection at once by selecting the mwc file. Click the link on the right to download the entire collection of drug sensitive and resistant mutants of Influenza neuramindases. |
 influenza2.mwc |
| PubChem |
 Sialic acid is the normal substrate for the influenza neuraminidase protein. |
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| PubChem |
 Oseltamivir, or Tamiflu® is used to treat respiratory infections with the influenza virus. |
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| PDB |
 A drug sensitive influenza N2 neuraminidase bound to Oseltamivir (G39). |
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| PDB |
D151g, drug resistant variant of influenza N2 neuraminidase protein bound to Oseltamivir (G39) with glycine acid at position 151 instead of aspartic acid. |
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| PDB |
 A drug sensitive influenza B neuraminidase bound to Oseltamivir (G39). |
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| PDB |
I220l, drug resistant variant of Influenza B neuraminidase bound to Oseltamivir (G39) with leucine at position 220 instead of isoleucine. |
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| PDB |
 A drug sensitive Influenza N1 neuraminidase from the 2009 pandemic strain bound to Oseltamivir (G39). |
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| PDB |
I223r, drug resistant influenza N1 neuraminidase from the 2009 pandemic strain bound to Oseltamivir (G39) with an arginine at position 223 instead of isoleucine. |
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| MMDB |
 A drug sensitive influenza N9 neuraminidase bound to Oseltamivir (G39). |
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| MMDB |
R292k, drug resistant influenza N9 neuraminidase bound to Oseltamivir (G39), with lysine replacing arginine. |
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| PDB |
 A drug sensitive influenza N9 neuraminidase bound to Oseltamivir (G39). |
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| PDB |
R294k, drug resistant influenza N9 neuraminidase bound to Oseltamivir (G39) with lysine at position 294 instead of arginine. |
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| PDB |
 N294, drug sensistive influenza N1 neuraminidase bound to Oseltamivir (G39). |
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| PDB |
N294s, drug resistant influenza N1 neuraminidase with serine at position 294 instead of asparagine bound to Oseltamivir (G39). |
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| PubChem |
 Lanamivir is used to treat respiratory infections with the influenza virus |
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| PDB |
 A drug sensitive influenza N9 neuraminidase bound to Lanamivir (LNV) |
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| PDB |
R294k, drug resistant influenza N9 neuraminidase bound to Lanamivir (LNV) with lysine at position 294 instead of arginine. |
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| MMDB |
 A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ). |
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| MMDB |
 E119g, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ) with a glycine at position 119 instead of glutamic acid. |
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| PubChem |
 Peramivir is used to treat respiratory infections with the influenza virus. |
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| MMDB |
 A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ). |
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| MMDB |
R292k, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ), with a lysine at position 292 instead of arginine. |
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| PDB |
 A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ). |
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| PDB |
R294k, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ) with lysine at position 294 instead of arginine. |
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| PubChem |
 Zanamivir (Relenza®) is used to treat respiratory infections with the influenza virus. |
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| PDB |
 A drug sensitive influenza N1 neuraminidase from the 2009 pandemic strain bound to Zanamivir (ZMR). |
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| PDB |
I223r, drug resistant influenza N1 neuraminidase from the 2009 pandemic strain bound to Zanamivir (ZMR) with arginine at position 223 instead of isoleucine. |
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| PDB |
 A drug sensitive influenza N9 neuraminidase bound to Zanamivir (ZMR). |
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| PDB |
R294k, drug resistant influenza N9 neuraminidase bound to Zanamivir (ZMR), with arginine at position 294 instead of lysine. |
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| PubChem |
 G20 is a compound being tested as a treatment for respiratory infections with the influenza virus. |
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| MMDB |
A drug sensitive influenza N9 neuraminidase bound to a new drug (G20). |
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| MMDB |
R292k, drug resistant, influenza N9 neuraminidase bound to a new drug (G20), with lysine at position 292 instead of arginine. |
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| PubChem |
 G28 is a compound being tested as a treatment for respiratory infections with the influenza virus. |
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| MMDB |
 A drug sensitive influenza N9 neuraminidase bound to a new drug (G28). |
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| MMDB |
R292k, drug resistant influenza N9 neuraminidase bound to a new drug (G28), with lysine at position 292 instead of arginine. |