Influenza-drug-resistance Collection

These structures are from aligned pairs of drug-sensitive and drug-resistant influenza proteins bound to different types of antiviral drugs. Comparing the pairs of structures shows how a single base mutation can allow a virus to become resistant to a drug. The drugs include Oseltamivir (Tamil®), Zanamivir (Relenza®), Peramivir (Rapivab®), Lanamivir, and two drug candidates (G20 and G28). The normal substrate, sialic acid, is also shown below.

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Structures in the collection

Type Description Download structure
An MW Collection

To view the collection, you will need to download and install the iPad version of Molecule World.  Once Molecule World is installed on your iPad, return to this page and download the entire collection at once by selecting the mwc file.  Click the link on the right to download the entire collection of drug sensitive and resistant mutants of Influenza neuramindases.  

Binary Data influenza2.mwc
PubChem

Sialic acid is the normal substrate for the influenza neuraminidase protein.

PubChem

Oseltamivir, or Tamiflu® is used to treat respiratory infections with the influenza virus.

PDB

A drug sensitive influenza N2 neuraminidase bound to Oseltamivir (G39).

PDB

D151g, drug resistant variant of influenza N2 neuraminidase protein bound to Oseltamivir (G39) with glycine acid at position 151 instead of aspartic acid.

PDB

A drug sensitive influenza B neuraminidase bound to Oseltamivir (G39).  

PDB

I220l, drug resistant variant of Influenza B neuraminidase bound to Oseltamivir (G39) with leucine at position 220 instead of isoleucine.

PDB

A drug sensitive Influenza N1 neuraminidase from the 2009 pandemic strain bound to Oseltamivir (G39).

PDB

I223r, drug resistant influenza N1 neuraminidase from the 2009 pandemic strain bound to Oseltamivir (G39) with an arginine at position 223 instead of isoleucine.

MMDB

A drug sensitive influenza N9 neuraminidase bound to Oseltamivir (G39).

MMDB

R292k, drug resistant influenza N9 neuraminidase bound to Oseltamivir (G39), with lysine replacing arginine.

PDB

A drug sensitive influenza N9 neuraminidase bound to Oseltamivir (G39).

PDB

R294k, drug resistant influenza N9 neuraminidase bound to Oseltamivir (G39) with lysine at position 294 instead of arginine.

PDB

N294, drug sensistive influenza N1 neuraminidase bound to Oseltamivir (G39).

PDB

N294s, drug resistant influenza N1 neuraminidase with serine at position 294 instead of asparagine bound to Oseltamivir (G39).

PubChem

Lanamivir is used to treat respiratory infections with the influenza virus

PDB

A drug sensitive influenza N9 neuraminidase bound to Lanamivir (LNV)

PDB

R294k, drug resistant influenza N9 neuraminidase bound to Lanamivir (LNV) with lysine at position 294 instead of arginine.

MMDB

A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ).

MMDB

E119g, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ) with a glycine at position 119 instead of glutamic acid.

PubChem

Peramivir is used to treat respiratory infections with the influenza virus.  

MMDB

A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ). 

MMDB

R292k, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ), with a lysine at position 292 instead of arginine.

PDB

A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ). 

PDB

R294k, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ) with lysine at position 294 instead of arginine.

PubChem

Zanamivir (Relenza®) is used to treat respiratory infections with the influenza virus.

PDB

A drug sensitive influenza N1 neuraminidase from the 2009 pandemic strain bound to Zanamivir (ZMR).

PDB

I223r, drug resistant influenza N1 neuraminidase from the 2009 pandemic strain bound to Zanamivir (ZMR) with arginine at position 223 instead of isoleucine.

PDB

A drug sensitive influenza N9 neuraminidase bound to Zanamivir (ZMR).

PDB

R294k, drug resistant influenza N9 neuraminidase bound to Zanamivir (ZMR), with arginine at position 294 instead of lysine.

PubChem

G20 is a compound being tested as a treatment for respiratory infections with the influenza virus.

MMDB

A drug sensitive influenza N9 neuraminidase bound to a new drug (G20).

MMDB

R292k, drug resistant, influenza N9 neuraminidase bound to a new drug (G20), with lysine at position 292 instead of arginine.

PubChem

G28 is a compound being tested as a treatment for respiratory infections with the influenza virus.

MMDB

A drug sensitive influenza N9 neuraminidase bound to a new drug (G28).

MMDB

R292k, drug resistant influenza N9 neuraminidase bound to a new drug (G28), with lysine at position 292 instead of arginine.