This transmission electron microscope image shows 2019-nCoV, the virus that causes COVID-19, isolated from a patient in the U.S., and emerging from the surface of cells cultured in the lab.
Credit: NIAID-RML
Note: the official name for the disease is COVID-19. The virus that causes the disease is known as nCoV, and 2019-nCoV, and sometimes SARS-CoV-2.
Resources for teaching:
1. Coronavirus images from NIAID-RML, from the Public Health Image Library
2. A map showing how the virus spread Healthmap.org/covid-19 and another map from Johns Hopkins University
3. My favorite dashboard https://coronavirus.1point3acres.com/
4. Current information on the outbreak: CDC Coronavirus Disease 2019
5. What is it like to have COVID-19? What effects does it have on your body? National Geographic: Here's what coronavirus does to the body
7. Life cycle SARS-CoV-2
8. The annotated Novel Coronavirus proteome from ViralZone
9. SARS-CoV-2 DNA and RNA sequences at the NCBI
11. Where did SARS-CoV-2 come from?
Reference sequence: ref|NC_045512
Other coronaviruses:
gb|MG772933.1
gb|MN996532.1
gb|AY304486
gb|AY390556.1
gb|MT040335.1
gb|MK564475.1
ref|NC_006577.2
NC_005831.2
gb|KF294372.1
AY994055.1
AJ271965.2
NC_002645.1
NC_010646.1
NC_038294.1
NC_009021.1
NC_019843.3
NC_017083.1
NC_004718.3
NC_014470.1
Pick discontinuous megablast as the program - this is best for cross species comparisons.
9. nCoV phylogeny vs geography
March 4th - Community transmission or travel?
April 3rd - COVID-19 in Iceland
April 17th - States are not islands or What happens in one state does not stay in that state.
10. Structures:
6M0J Receptor domain of SARS-CoV2 spike protein bound to ACE2
6YLA = SARS-CoV-2 spike bound to Fab CR3022
Science paper about neutralizing antibodies: A Highly Conserved Cryptic Epitope in the Receptor-Binding Domains of SARS-CoV-2 and SARS-CoV
The SARS-CoV-2 spike protein and ACE2 and the ACE2 binding domain from SARS-CoV2 bound to a neutralizing antibody.
10. Structures of antibodies bound to SARS or MERS proteins.
11. Companies working on COVID-19 tests, vaccines, treatments.
12. Spread sheet for NCoV -19 proteins
Articles:
Galasiti Kankanamalage AC, Kim Y, Damalanka VC, et al. Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element. Eur J Med Chem. 2018;150:334–346. doi:10.1016/j.ejmech.2018.03.004
Kim Y, Liu H, Galasiti Kankanamalage AC, et al. Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor [published correction appears in PLoS Pathog. 2016 May;12(5):e1005650]. PLoS Pathog. 2016;12(3):e1005531. Published 2016 Mar 30. doi:10.1371/journal.ppat.1005531
Takano T, Akiyama M, Doki T, Hohdatsu T. Antiviral activity of itraconazole against type I feline coronavirus infection. Vet Res. 2019;50(1):5. Published 2019 Jan 18. doi:10.1186/s13567-019-0625-3