Influenza-drug-resistance Collection

These structures are from aligned pairs of drug-sensitive and drug-resistant influenza proteins bound to different types of antiviral drugs. Comparing the pairs of structures shows how a single base mutation can allow a virus to become resistant to a drug. The drugs include Oseltamivir (Tamil®), Zanamivir (Relenza®), Peramivir (Rapivab®), Lanamivir, and two drug candidates (G20 and G28). The normal substrate, sialic acid, is also shown below.


Structures in the collection

Type Description Download structure
An MW Collection

Click the link on the right to download the entire collection of drug sensitive and resistant mutants of Influenza neuramindases.

Binary Data influenza2.mwc
PubChem

Sialic acid is the normal substrate for the influenza neuraminidase protein.

Binary Data sialic_acid.sdf.gz
PubChem

Oseltamivir, or Tamiflu® is used to treat respiratory infections with the influenza virus.

Binary Data oseltamivir.sdf.gz
PDB

A drug sensitive influenza N2 neuraminidase bound to Oseltamivir (G39).

Binary Data 4GZP.pdb.gz
PDB

D151g, drug resistant variant of influenza N2 neuraminidase protein bound to Oseltamivir (G39) with glycine acid at position 151 instead of aspartic acid.

Binary Data 4GZT_aligned.pdb.gz
PDB

A drug sensitive influenza B neuraminidase bound to Oseltamivir (G39).  

Binary Data 4CPM.pdb.gz
PDB

I220l, drug resistant variant of Influenza B neuraminidase bound to Oseltamivir (G39) with leucine at position 220 instead of isoleucine.

Binary Data 4CPY_aligned.pdb.gz
PDB

A drug sensitive Influenza N1 neuraminidase from the 2009 pandemic strain bound to Oseltamivir (G39).

Binary Data 4B7R.pdb.gz
PDB

I223r, drug resistant influenza N1 neuraminidase from the 2009 pandemic strain bound to Oseltamivir (G39) with an arginine at position 223 instead of isoleucine.

Binary Data 4B7J_aligned.pdb.gz
MMDB

A drug sensitive influenza N9 neuraminidase bound to Oseltamivir (G39).

Binary Data 2QWK.cn3
MMDB

R292k, drug resistant influenza N9 neuraminidase bound to Oseltamivir (G39), with lysine replacing arginine.

Binary Data 2QWH.cn3
PDB

A drug sensitive influenza N9 neuraminidase bound to Oseltamivir (G39).

Binary Data 4MWQ.pdb.gz
PDB

R294k, drug resistant influenza N9 neuraminidase bound to Oseltamivir (G39) with lysine at position 294 instead of arginine.

Binary Data 4MWW_aligned.pdb.gz
PDB

N294, drug sensistive influenza N1 neuraminidase bound to Oseltamivir (G39).

Binary Data 2HU0_Bdrug.pdb.gz
PDB

N294s, drug resistant influenza N1 neuraminidase with serine at position 294 instead of asparagine bound to Oseltamivir (G39).

Binary Data 3CL2_Bdrug.pdb.gz
PubChem

Lanamivir is used to treat respiratory infections with the influenza virus

Binary Data lanamivir.sdf.gz
PDB

A drug sensitive influenza N9 neuraminidase bound to Lanamivir (LNV)

Binary Data 4MWU.pdb.gz
PDB

R294k, drug resistant influenza N9 neuraminidase bound to Lanamivir (LNV) with lysine at position 294 instead of arginine.

Binary Data 4MWY_aligned.pdb.gz
MMDB

A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ).

Binary Data 1L7F.cn3
MMDB

E119g, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ) with a glycine at position 119 instead of glutamic acid.

Binary Data 1L7G.cn3
PubChem

Peramivir is used to treat respiratory infections with the influenza virus.  

Binary Data peramivir.sdf.gz
MMDB

A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ). 

Binary Data 1L7F.cn3
MMDB

R292k, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ), with a lysine at position 292 instead of arginine.

Binary Data 1L7H.cn3
PDB

A drug sensitive influenza N9 neuraminidase bound to Peramivir (BCZ). 

Binary Data 4MWV.pdb.gz
PDB

R294k, drug resistant influenza N9 neuraminidase bound to Peramivir (BCZ) with lysine at position 294 instead of arginine.

Binary Data 4MX0_aligned.pdb.gz
PubChem

Zanamivir (Relenza®) is used to treat respiratory infections with the influenza virus.

Binary Data zanamivir.sdf.gz
PDB

A drug sensitive influenza N1 neuraminidase from the 2009 pandemic strain bound to Zanamivir (ZMR).

Binary Data 4B7Q.pdb.gz
PDB

I223r, drug resistant influenza N1 neuraminidase from the 2009 pandemic strain bound to Zanamivir (ZMR) with arginine at position 223 instead of isoleucine.

Binary Data 4B7N_aligned.pdb.gz
PDB

A drug sensitive influenza N9 neuraminidase bound to Zanamivir (ZMR).

Binary Data 4MWR.pdb.gz
PDB

R294k, drug resistant influenza N9 neuraminidase bound to Zanamivir (ZMR), with arginine at position 294 instead of lysine.

Binary Data 4MWX_aligned.pdb.gz
PubChem

G20 is a compound being tested as a treatment for respiratory infections with the influenza virus.

Binary Data G20.sdf.gz
MMDB

A drug sensitive influenza N9 neuraminidase bound to a new drug (G20).

Binary Data 2QWI.cn3
MMDB

R292k, drug resistant, influenza N9 neuraminidase bound to a new drug (G20), with lysine at position 292 instead of arginine.

Binary Data 2QWF.cn3
PubChem

G28 is a compound being tested as a treatment for respiratory infections with the influenza virus.

Binary Data G28.sdf.gz
MMDB

A drug sensitive influenza N9 neuraminidase bound to a new drug (G28).

Binary Data 2QWJ.cn3
MMDB

R292k, drug resistant influenza N9 neuraminidase bound to a new drug (G28), with lysine at position 292 instead of arginine.

Binary Data 2QWG.cn3