BRCA1 Collection

This collection of chemical and molecular structures has been assembled to complement the Bio-ITEST Genetic Testing curriculum strand. All the structures below can be viewed in Molecule World on the iPad or Molecule World for iPhone.   ****Includes NEW structures!****


Structures in the collection

Type Description Download structure
An MW Collection

Download the entire collection of BRCA1 structures by clicking the link in the next column.

Collections can be downloaded in one step and viewed in the iPad version of Molecule World.  Individual structures can be viewed in either version. Download individual structures using the links below.

Binary Data brca1.mwc
PDB

BRCA1 carboxyl terminal end with BRCT repeats, bound to CtIP phosphopeptide, a partner in detecting and repairing DNA.

Binary Data 1y98_aligned.pdb.gz
MMDB

BRCA1 carboxyl terminal end, contains BRCT repeats and the CtIP binding domain.  M1775

Binary Data mmdb_1JNX.cn3
MMDB

BRCA1 carboxyl terminal end, BRCT repeats.  Contains the CtIP binding domain and M1775r mutation.

Binary Data mmdb_1N5O.cn3
PDB

BRCA1 carboxyl terminal end, BRCT repeats.  Contains the CtIP binding domain and M1775k mutation.

Binary Data 2ing_aln2.pdb.gz
PDB

BRCA1 carboxyl terminal end, BRCT repeats.  Contains the T1700a missense mutation.

Binary Data 3pxb_aln.pdb.gz
PDB

Contains the T1700a missense mutation in the BRCA1 carboxyl terminal end.   Modeling was used to align 3PXB to 1Y98 and add the CtIP phosphopeptide.  

Binary Data 3pxb_ctip.pdb.gz
PDB

BRCA1 carboxyl terminal end, BRCT repeats.  Contains the V1809f missense mutation.

 

Binary Data 1t2u_aln.pdb.gz
PDB

Contains the V1809 missense mutation in the BRCA1 carboxyl terminal end.   Modeling was used to align 1T2U to 1Y98 and add the CtIP phosphopeptide. 

Binary Data 1t2u_ctip.pdb.gz
MMDB

A short chain of double-stranded DNA showing hydrogens. Hydrogens are present because this structure was solved by NMR.

Binary Data mmdb_1NAJ.cn3